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Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma.
Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma.
- Source :
-
Allergy [Allergy] 2012 Dec; Vol. 67 (12), pp. 1601-4. Date of Electronic Publication: 2012 Sep 25. - Publication Year :
- 2012
-
Abstract
- Background: Caveolin-1 has emerged as a critical regulator of signaling pathways involved in lung fibrosis and inflammation.<br />Methods: Therefore, we investigated whether caveolin-1 is deficient in asthmatic patients and in a murine model of asthma.<br />Results: Immunohistochemical analyses of endobronchial biopsies showed a remarkable loss of caveolin-1 in the lungs of asthmatic patients compared with controls. This loss was most evident in bronchial epithelial cells and associated with an increase in the expression of extracellular matrix proteins: collagen I, tenascin, and periostin. Cultured primary bronchial epithelial cells of asthmatics had lower caveolin-1 expression compared with control cells. In addition, caveolin-1 expression was significantly decreased in peripheral blood monocytes from asthma patients. The loss of caveolin-1 was also observed in a mouse model for asthma (mice sensitized and challenged with aspergillus fumigatus).<br />Conclusions: To our knowledge, this is the first demonstration that the regulatory protein caveolin-1 is reduced in patients with asthma.<br /> (© 2012 John Wiley & Sons A/S.)
Details
- Language :
- English
- ISSN :
- 1398-9995
- Volume :
- 67
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 23004679
- Full Text :
- https://doi.org/10.1111/all.12021