Purine metabolites in fibromyalgia syndrome.

Authors :: Fais A
Cacace E
Corda M
Era B
Peri M
Utzeri S
Ruggiero V
Source :: Clinical biochemistry [Clin Biochem] 2013 Jan; Vol. 46 (1-2), pp. 37-9. Date of Electronic Publication: 2012 Sep 18.
Publication Year :: 2013
Abstract: Objective: To evaluate serum purine metabolite concentrations in patients affected by fibromyalgia syndrome (FMS) and the relationships between their levels and FM clinical parameters.<br />Design and Methods: Serum purine levels were quantified using LC/UV-vis in 22 fibromyalgic females (according to the American College of Rheumatology classification criteria) and 22 healthy females.<br />Results: Significantly higher serum inosine, hypoxanthine and xanthine levels (p<0.001) and significantly lower serum adenosine (p<0.05) were detected in the FMS patients vs healthy controls. Our data show a negative correlation between adenosine and Fibromyalgia Impact Questionnaire (FIQ).<br />Conclusions: Study results suggest that purines, in particular adenosine and inosine, may be involved in pain transmission in fibromyalgia.<br /> (Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.)