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Histone methylation defines an epigenetic entity in penile squamous cell carcinoma.
- Source :
-
The Journal of urology [J Urol] 2013 Mar; Vol. 189 (3), pp. 1117-22. Date of Electronic Publication: 2012 Oct 08. - Publication Year :
- 2013
-
Abstract
- Purpose: Earlier studies indicate that epigenetics contribute to the pathogenesis of penile squamous cell carcinoma. Histone methylation patterns are frequently altered during carcinogenesis. Therefore, we investigated the methylation pattern of the histones H3K4, H3K9 and H3K27 in penile carcinoma and normal tissue.<br />Materials and Methods: A tissue microarray was constructed with 65 penile carcinomas, 6 metastatic lesions and 30 control tissues. Global histone methylation was assessed using immunohistochemistry.<br />Results: Global levels of H3K4me1, H3K9me1, H3K9me2, H3K27me2 and H3K27me3 were decreased, whereas H3K9me3 was increased in penile carcinoma. Histone methylation levels defined an epigenetic entity that allowed accurate differentiation of cancer and normal samples. We observed no correlation of histone methylation levels with clinicopathological parameters or patient outcome.<br />Conclusions: The description of a definite epigenetic entity in penile carcinoma provides a rationale for testing epigenetic agents in patients with metastatic disease.<br /> (Copyright © 2013 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Epigenomics methods
Histones metabolism
Humans
Immunohistochemistry
Male
Methylation
Middle Aged
Penile Neoplasms metabolism
Penile Neoplasms pathology
Prognosis
Carcinoma, Squamous Cell genetics
Epigenesis, Genetic
Histones genetics
Penile Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1527-3792
- Volume :
- 189
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of urology
- Publication Type :
- Academic Journal
- Accession number :
- 22999995
- Full Text :
- https://doi.org/10.1016/j.juro.2012.08.221