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Low serum levels of vitamin D in idiopathic inflammatory myopathies.
- Source :
-
Annals of the rheumatic diseases [Ann Rheum Dis] 2013 Apr; Vol. 72 (4), pp. 512-6. Date of Electronic Publication: 2012 Sep 19. - Publication Year :
- 2013
-
Abstract
- Objectives: To evaluate serum levels of 25(OH) vitamin D in patients with idiopathic inflammatory myopathies (IIM) (polymyositis (PM), dermatomyosistis (DM), inclusion body myositis (IBM) and juvenile DM (JDM)) and to compare these with healthy controls.<br />Methods: Serum samples from 149 patients with IIM and 290 healthy controls matched for gender and the month of blood sampling were analysed for 25(OH) vitamin D. ORs for vitamin D classes with 95% CI were calculated using a matched (conditional) logistic regression model. Groups were compared by the Kruskal-Wallis test and p values <0.05 were considered significant.<br />Results: Patients with IIM had significantly lower serum levels of 25(OH) vitamin D than healthy controls (median 39 (10-168) nmol/l vs 68 (19-197) nmol/l; p=0.0001). There was no significant difference in vitamin D levels between the myositis subgroups. When vitamin D levels were subclassified into deficient (<50 nmol/l), insufficient (50-74 nmol/l) and normal (≥75 nmol/l), most of the patients with PM (68%), DM (65%) and IBM (53%) had deficient levels compared with only 60 (21%) healthy individuals. In patients with IIM the OR for deficient versus normal was 17.7 (95% CI 8.1 to 38.6) and the OR for insufficient versus normal was 2.4 (95% CI 1.2 to 4.7).<br />Conclusions: Low serum levels of vitamin D were found in most patients with IIM and may confer a risk factor for developing adult myositis, similar to some other autoimmune diseases.
- Subjects :
- Adolescent
Adult
Aged
Cross-Sectional Studies
Dermatomyositis blood
Dermatomyositis epidemiology
Female
Humans
Logistic Models
Male
Middle Aged
Myositis blood
Myositis, Inclusion Body blood
Myositis, Inclusion Body epidemiology
Polymyositis blood
Polymyositis epidemiology
Retrospective Studies
Risk Factors
Vitamin D blood
Vitamin D Deficiency blood
Young Adult
Myositis epidemiology
Vitamin D analogs & derivatives
Vitamin D Deficiency epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2060
- Volume :
- 72
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Annals of the rheumatic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22993226
- Full Text :
- https://doi.org/10.1136/annrheumdis-2012-201849