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Evaluation of thermoresponsive properties and biocompatibility of polybenzofulvene aggregates for leuprolide delivery.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2012 Nov 15; Vol. 438 (1-2), pp. 279-86. Date of Electronic Publication: 2012 Sep 16. - Publication Year :
- 2012
-
Abstract
- In this study, a polybenzofulvene derivative named poly-6-MOEG-9-BF3k, was evaluated as polymeric material for the production of injectable thermoresponsive nano-aggregates able to load low molecular weight peptidic drug, like the anticancer leuprolide. Thermoresponsive behavior of poly-6-MOEG-9-BF3k was studied in aqueous media by evaluating scattering intensity variations by means of DLS in function of temperature. Zeta potential measurements and SEM observations were also carried out. Moreover, critical aggregation temperature of the poly-6-MOEG-9-BF3k polymer was evaluated by pyrene fluorescence analysis. Then, the ability of prepared thermoresponsive aggregates to protect this model oligopeptide drug and regulate its release rate in function of external temperature was evaluated in vitro. Finally, biocompatibility of poly-6-MOEG-9-BF3k aggregates was tested in vitro on a healthy cell line (human bronchial epithelial cell; 16-HBE) and in vivo on rat animal model upon subcutaneous administration.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents, Hormonal chemistry
Cell Line
Cell Survival drug effects
Drug Carriers chemistry
Humans
Indenes chemistry
Leuprolide chemistry
Male
Microscopy, Electron, Scanning
Nanostructures chemistry
Nanostructures ultrastructure
Polymers chemistry
Rats
Rats, Wistar
Skin anatomy & histology
Skin drug effects
Temperature
Antineoplastic Agents, Hormonal administration & dosage
Drug Carriers administration & dosage
Indenes administration & dosage
Leuprolide administration & dosage
Nanostructures administration & dosage
Polymers administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 438
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 22989982
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2012.09.023