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Acneiform eruptions induced by epidermal growth factor receptor inhibitors: treatment with oral isotretinoin.
- Source :
-
Cutis [Cutis] 2012 Aug; Vol. 90 (2), pp. 77-80. - Publication Year :
- 2012
-
Abstract
- The most common cutaneous side effects to epidermal growth factor receptor (EGFR) inhibitors are follicular or acneiform eruptions, nail disorders, xerosis, and desquamation. Although topical and oral antibiotics with or without topical corticosteroids usually are safe and effective treatment options for acneiform eruptions due to EGFR inhibitors, they are not always successful in refractory cases. We report 3 cases of severe acneiform eruptions induced by EGFR inhibitors that were successfully treated with oral isotretinoin. Complete response was observed in all 3 patients. We recommend oral isotretinoin for the management of acneiform reactions to EGFR inhibitors when the lesions persist or worsen despite antibiotic treatment.
- Subjects :
- Acneiform Eruptions chemically induced
Aged
Antibodies, Monoclonal adverse effects
Antibodies, Monoclonal, Humanized
Antineoplastic Agents adverse effects
Cetuximab
Dermatologic Agents administration & dosage
Erlotinib Hydrochloride
Female
Humans
Isotretinoin administration & dosage
Male
Quinazolines adverse effects
Acneiform Eruptions drug therapy
Dermatologic Agents therapeutic use
Drug Eruptions drug therapy
ErbB Receptors antagonists & inhibitors
Isotretinoin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0011-4162
- Volume :
- 90
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cutis
- Publication Type :
- Academic Journal
- Accession number :
- 22988651