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The expression of calretinin and cytokeratins in canine acanthomatous ameloblastoma and oral squamous cell carcinoma.
- Source :
-
Veterinary and comparative oncology [Vet Comp Oncol] 2014 Dec; Vol. 12 (4), pp. 258-65. Date of Electronic Publication: 2012 Sep 18. - Publication Year :
- 2014
-
Abstract
- Oral squamous cell carcinoma (OSCC) and canine acanthomatous ameloblastoma (CAA) represent two epithelium-derived neoplasms that affect the oral cavity of dogs. The expression of cytokeratins (CKs) and calretinin has been previously established in the canine tooth bud and odontogenic tumours. The aim of this study was to characterize the CK and calretinin expression profile of OSCC in comparison to CAA and canine tooth bud tissues. Samples from 15 OSCC and 15 CAA cases, as well as 6 tooth buds and 2 normal gingival tissues were examined. OSCC CK expression was consistent with the CK expression profile of CAA and canine tooth bud tissue. Calretinin was positively expressed in 10 of 15 OSCC cases, with 5 cases demonstrating high staining intensity. Only 2 of 15 CAA cases demonstrated mild-moderate staining intensity. The statistically significant difference in staining pattern and intensity of calretinin in OSCC and CAA can help distinguish between these two tumour types.<br /> (© 2012 Blackwell Publishing Ltd.)
- Subjects :
- Ameloblastoma metabolism
Ameloblastoma pathology
Animals
Antibodies, Monoclonal
California
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Dog Diseases pathology
Dogs
Immunohistochemistry veterinary
Jaw Neoplasms metabolism
Jaw Neoplasms pathology
Mouth Neoplasms metabolism
Mouth Neoplasms pathology
Tooth pathology
Universities
Ameloblastoma veterinary
Calbindin 2 metabolism
Carcinoma, Squamous Cell veterinary
Dog Diseases metabolism
Jaw Neoplasms veterinary
Keratins metabolism
Mouth Neoplasms veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5829
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Veterinary and comparative oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22985095
- Full Text :
- https://doi.org/10.1111/j.1476-5829.2012.00356.x