Back to Search
Start Over
The Mediator complex and transcription elongation.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2013 Jan; Vol. 1829 (1), pp. 69-75. Date of Electronic Publication: 2012 Sep 13. - Publication Year :
- 2013
-
Abstract
- Background: Mediator is an evolutionarily conserved multisubunit RNA polymerase II (Pol II) coregulatory complex. Although Mediator was initially found to play a critical role in the regulation of the initiation of Pol II transcription, recent studies have brought to light an expanded role for Mediator at post-initiation stages of transcription.<br />Scope of Review: We provide a brief description of the structure of Mediator and its function in the regulation of Pol II transcription initiation, and we summarize recent findings implicating Mediator in the regulation of various stages of Pol II transcription elongation.<br />Major Conclusions: Emerging evidence is revealing new roles for Mediator in nearly all stages of Pol II transcription, including initiation, promoter escape, elongation, pre-mRNA processing, and termination.<br />General Significance: Mediator plays a central role in the regulation of gene expression by impacting nearly all stages of mRNA synthesis. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.<br /> (Copyright © 2012. Published by Elsevier B.V.)
- Subjects :
- Animals
Humans
Mediator Complex chemistry
Mediator Complex genetics
Mediator Complex metabolism
Models, Biological
RNA Polymerase II chemistry
RNA Polymerase II genetics
RNA Polymerase II metabolism
RNA Polymerase II physiology
Structure-Activity Relationship
Mediator Complex physiology
Transcription Elongation, Genetic physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1829
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 22983086
- Full Text :
- https://doi.org/10.1016/j.bbagrm.2012.08.017