Cytosolic lipid inclusions formed during infection by viral and bacterial pathogens.

Authors :: Stehr M
Elamin AA
Singh M
Source :: Microbes and infection [Microbes Infect] 2012 Nov; Vol. 14 (13), pp. 1227-37. Date of Electronic Publication: 2012 Aug 30.
Publication Year :: 2012
Abstract: Lipid inclusions play an important role in several pathological processes. Intracellular bacterial pathogens, such as members of the Mycobacterium and Chlamydia species are able to trigger the formation of lipid-laden foamy macrophages. Lipid droplet accumulation in the host constitutes a reservoir used by the bacilli for long-term persistence. Viruses need lipid droplets as assembly platform. We present the current knowledge about structural, functional and regulatory aspects of lipid inclusions.<br /> (Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)

Subjects :: Animals
Chlamydia physiology
Chlamydia Infections metabolism
Chlamydia Infections microbiology
Cytosol metabolism
Host-Pathogen Interactions
Humans
Lipid Metabolism
Lipids genetics
Mycobacterium physiology
Mycobacterium Infections metabolism
Mycobacterium Infections microbiology
Virus Diseases metabolism
Virus Diseases virology
Foam Cells microbiology
Inclusion Bodies metabolism
Lipids chemistry
Macrophages microbiology

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