Back to Search
Start Over
Manganese alters rat brain amino acids levels.
- Source :
-
Biological trace element research [Biol Trace Elem Res] 2012 Dec; Vol. 150 (1-3), pp. 337-41. Date of Electronic Publication: 2012 Sep 13. - Publication Year :
- 2012
-
Abstract
- Manganese (Mn) is an essential element and it acts as a cofactor for a number of enzymatic reactions, including those involved in amino acid, lipid, protein, and carbohydrate metabolism. Excessive exposure to Mn can lead to poisoning, characterized by psychiatric disturbances and an extrapyramidal disorder. Mn-induced neuronal degeneration is associated with alterations in amino acids metabolism. In the present study, we analyzed whole rat brain amino acid content subsequent to four or eight intraperitoneal injections, with 25 mg MnCl₂/kg/day, at 48-h intervals. We noted a significant increase in glycine brain levels after four or eight Mn injections (p < 0.05 and p < 0.01, respectively) and arginine also after four or eight injections (p < 0.001). Significant increases were also noted in brain proline (p < 0.01), cysteine (p < 0.05), phenylalanine (p < 0.01), and tyrosine (p < 0.01) levels after eight Mn injections vs. the control group. These findings suggest that Mn-induced alterations in amino acid levels secondary to Mn affect the neurochemical milieu.
- Subjects :
- Animals
Brain metabolism
Chlorides administration & dosage
Chlorides analysis
Chlorides pharmacokinetics
Dose-Response Relationship, Drug
Extrapyramidal Tracts drug effects
Extrapyramidal Tracts metabolism
Injections, Intraperitoneal
Male
Manganese analysis
Manganese Compounds administration & dosage
Manganese Compounds analysis
Manganese Compounds pharmacokinetics
Neurodegenerative Diseases etiology
Neurons metabolism
Neurotoxicity Syndromes physiopathology
Random Allocation
Rats
Rats, Wistar
Tissue Distribution
gamma-Aminobutyric Acid metabolism
Amino Acids metabolism
Brain drug effects
Brain Chemistry drug effects
Manganese Poisoning metabolism
Neurons drug effects
Neurotoxicity Syndromes metabolism
Up-Regulation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0720
- Volume :
- 150
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Biological trace element research
- Publication Type :
- Academic Journal
- Accession number :
- 22971893
- Full Text :
- https://doi.org/10.1007/s12011-012-9504-8