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[Cost-effectiveness evaluation of seven screening strategies for nasopharyngeal carcinoma].
- Source :
-
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2012 Jul; Vol. 34 (7), pp. 549-53. - Publication Year :
- 2012
-
Abstract
- Objective: To evaluate the cost-effectiveness of different screening strategies for nasopharyngeal carcinoma (NPC) and recommend a preferable NPC screening strategy.<br />Methods: A Markov simulation model was constructed based on the natural history of NPC. Seven strategies (A. Annual screening; B. Annual screening for (Epstein-Barr virus, EBV) EBV-seropositive subjects, triennial screening for seronegative subjects; C. Biennial screening; D. Triennial screening; E. 4-year screening; F. 5-year screening; G. 6-year screening) were evaluated. The NPC-pickup rate, cost, quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratio (ICER) were calculated.<br />Results: The ICERs of the 7 strategies were 83 111.6, 47 768.9, 50 164.7, 40 016.2, 34 272.8, 32 215.6, and 32 248.0 Yuan/QALY, respectively. The discounted QALYs of the strategies were 23 079.9, 22 955.6, 22 810.4, 22 636.5, 22 522.7, 22 445.0, and 22 361.9 years, respectively. The ICERs of the strategies were less than three times of the average per capita gross domestic product (89 976 Yuan) in China in 2010. The strategy A achieved a highest NPC pick-up rate (81.7%), a highest discounted QALY and a smallest number of NPC death (681), but a highest discounted cost and a greatest ICER. Compared with the strategy A, the strategy B achieved a little smaller NPC pick-up rate (73.1%), a little smaller number of NPC death (707), however, the ICER of the strategy B decreased by 38.2%.<br />Conclusion: The strategy B (annual screening for EB virus seropositive subjects and triennial screening for seronegative subjects) is a preferable option for NPC screening.
- Subjects :
- Adult
Carcinoma
China epidemiology
Cost-Benefit Analysis
Early Detection of Cancer economics
Epstein-Barr Virus Infections diagnosis
Female
Humans
Male
Markov Chains
Mass Screening economics
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms mortality
Quality-Adjusted Life Years
Survival Rate
Early Detection of Cancer methods
Herpesvirus 4, Human isolation & purification
Mass Screening methods
Nasopharyngeal Neoplasms diagnosis
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-3766
- Volume :
- 34
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Zhonghua zhong liu za zhi [Chinese journal of oncology]
- Publication Type :
- Academic Journal
- Accession number :
- 22967476
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0253-3766.2012.07.015