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Both acute and chronic placental inflammation are overrepresented in term stillbirths: a case-control study.
- Source :
-
Infectious diseases in obstetrics and gynecology [Infect Dis Obstet Gynecol] 2012; Vol. 2012, pp. 293867. Date of Electronic Publication: 2012 Aug 26. - Publication Year :
- 2012
-
Abstract
- Objective: To elucidate differences in the frequency and severity of acute chorioamnionitis (CAM) and chronic villitis in placentas from stillborns compared with liveborns at term and to evaluate other risk factors and placental findings.<br />Design: Case-control study.<br />Setting: All delivery wards in major Stockholm area. Population or Sample. Placentas from stillborn/case (n = 126) and liveborn/control (n = 273) neonates were prospectively collected between 2002 and 2005.<br />Methods: CAM was assessed on a three-grade scale based on the presence and distribution of polymorphonuclear leucocytes in the chorion/amnion. The presence of vasculitis and funisitis was recorded separately. Chronic villitis was diagnosed by the presence of mononuclear cells in the villous stroma. Relevant clinical data were collected from a specially constructed, web-based database. The statistic analyses were performed using multivariable logistic regression.<br />Results: CAM (especially severe, AOR: 7.39 CI: 3.05-17.95), villous immaturity (AOR: 7.17 CI: 2.66-19.33), villitis (<1 % AOR: 4.31 CI: 1.16-15.98; ≥ 1 %, AOR: 3.87 CI: 1.38-10.83), SGA (AOR: 7.52 CI: 3.06-18.48), and BMI >24.9 (AOR: 2.06 CI: 1.21-3.51) were all connected to an elevated risk of term stillbirth.<br />Conclusions: We found that CAM, chronic villitis, villous immaturity, SGA, and maternal overweight, but not vasculitis or funisitis are independently associated with risk for stillbirth at term.
- Subjects :
- Acute Disease
Adult
Case-Control Studies
Chorioamnionitis diagnosis
Chorioamnionitis epidemiology
Chronic Disease
Female
Humans
Infant, Newborn
Multivariate Analysis
Placenta Diseases diagnosis
Pregnancy
Prevalence
Prospective Studies
Risk Factors
Sweden epidemiology
Young Adult
Placenta Diseases epidemiology
Stillbirth
Subjects
Details
- Language :
- English
- ISSN :
- 1098-0997
- Volume :
- 2012
- Database :
- MEDLINE
- Journal :
- Infectious diseases in obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 22966214
- Full Text :
- https://doi.org/10.1155/2012/293867