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Early functional impairment in bipolar youth: a nested population-based case-control study.
- Source :
-
Journal of affective disorders [J Affect Disord] 2012 Dec 15; Vol. 142 (1-3), pp. 208-12. Date of Electronic Publication: 2012 Sep 07. - Publication Year :
- 2012
-
Abstract
- Objectives: The objective of this report is to evaluate functioning in bipolar disorder in a population-based sample of young adults (18 to 24 years old). To this end, people with bipolar disorder were compared with matched participants with only depressive episodes and control subjects without a history of mood episodes.<br />Methods: Case-control study nested in a population-based sample. Caseness was confirmed with the Structured Clinical Interview for DSM-IV. The Functioning Assessment Short Test was used as a measure of general functioning. A multivariate model was elaborated to account for potential confounders.<br />Results: The sample consisted of 231 subjects. Both bipolar disorder (coef=0.60, SE=0.14, p<0.001) and major depression (coef=0.44, SE=0.14, p=0.001) were associated with functioning in the multivariate model. Current depressive symptoms appeared to influence functioning in those with major depression (Z=2.05, p=0.04), but not in those with bipolar disorder (Z=0.78, p=0.43).<br />Limitation: Neuropsychological testing was not performed and we see it as an important limitation of this study.<br />Conclusion: This population-based study further reinforces the notion that functional impairment is a fundamental characteristic of bipolar illness. It is present from early stages and is not completely explained by mood symptoms.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Bipolar Disorder diagnosis
Case-Control Studies
Comorbidity
Cross-Sectional Studies
Diagnostic and Statistical Manual of Mental Disorders
Early Diagnosis
Female
Humans
Male
Multivariate Analysis
Substance-Related Disorders epidemiology
Bipolar Disorder epidemiology
Bipolar Disorder physiopathology
Depressive Disorder, Major epidemiology
Depressive Disorder, Major physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 142
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 22959682
- Full Text :
- https://doi.org/10.1016/j.jad.2012.04.028