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Moraxella catarrhalis: from interactions with the host immune system to vaccine development.
- Source :
-
Future microbiology [Future Microbiol] 2012 Sep; Vol. 7 (9), pp. 1073-100. - Publication Year :
- 2012
-
Abstract
- Moraxella catarrhalis is a human-restricted commensal that over the last two decades has developed into an emerging respiratory tract pathogen. The bacterial species is equipped with various adhesins to facilitate its colonization. Successful evasion of the human immune system is a prerequisite for Moraxella infection. This strategy involves induction of an excessive proinflammatory response, intervention of granulocyte recruitment to the infection site, activation of selected pattern recognition receptors and cellular adhesion molecules to counteract the host bacteriolytic attack, as well as, finally, reprogramming of antigen presenting cells. Host immunomodulator molecules are also exploited by Moraxella to aid in resistance against complement killing and host bactericidal molecules. Thus, breaking the basis of Moraxella immune evasion mechanisms is fundamental for future invention of effective therapy in controlling Moraxella infection.
- Subjects :
- Bacterial Adhesion
Humans
Immune Evasion
Moraxella catarrhalis genetics
Moraxellaceae Infections immunology
Moraxellaceae Infections microbiology
Moraxellaceae Infections prevention & control
Nasopharynx microbiology
Respiratory Tract Infections immunology
Respiratory Tract Infections microbiology
Adhesins, Bacterial metabolism
Bacterial Vaccines immunology
Moraxella catarrhalis pathogenicity
Moraxella catarrhalis physiology
Respiratory Tract Infections prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1746-0921
- Volume :
- 7
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Future microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 22953708
- Full Text :
- https://doi.org/10.2217/fmb.12.80