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Does protein phosphorylation govern host cell entry and egress by the Apicomplexa?
- Source :
-
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2012 Oct; Vol. 302 (4-5), pp. 195-202. Date of Electronic Publication: 2012 Aug 27. - Publication Year :
- 2012
-
Abstract
- Members of the phylum Apicomplexa are responsible for a wide range of diseases in humans and animals. The absence of an effective vaccine or safe curing drugs and the continuous emergence of resistant parasites to available treatments impose a high demand on the identification of novel targets for intervention against the apicomplexans. Protein kinases are considered attractive potential therapeutic targets not only against cancers but also to combat infectious diseases. The scope and aim of this review is to report on the recent progress in dissecting the impact of protein phosphorylation in regulating motility and invasion.<br /> (Copyright © 2012 Elsevier GmbH. All rights reserved.)
- Subjects :
- Actins chemistry
Animals
Antigens, Protozoan chemistry
Binding Sites
Calcium chemistry
Calcium Signaling
Host-Parasite Interactions
Humans
Membrane Proteins chemistry
Phosphoproteins chemistry
Phosphorylation
Protein Kinases chemistry
Protozoan Proteins chemistry
Apicomplexa chemistry
Apicomplexa pathogenicity
Protozoan Infections parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0607
- Volume :
- 302
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- International journal of medical microbiology : IJMM
- Publication Type :
- Academic Journal
- Accession number :
- 22951234
- Full Text :
- https://doi.org/10.1016/j.ijmm.2012.07.012