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Significant improvement in statin adherence and cholesterol levels after acute myocardial infarction.
- Source :
-
Danish medical journal [Dan Med J] 2012 Sep; Vol. 59 (9), pp. A4509. - Publication Year :
- 2012
-
Abstract
- Introduction: Not all patients recovering from acute myocardial infarction (AMI) are optimally treated with statin, and their adherence to statin treatment may be inadequate. We set out to describe changes in statin treatment adherence and cholesterol values over time.<br />Material and Methods: Data from two cohorts of AMI patients discharged from the Department of Cardiology, Odense University Hospital, in 2003 (n = 474, mean age 68 years, 66% males) and 2008 (n = 550, mean age 67 years, 69% males) were compared. Based on the number of tablets collected at the pharmacy, patients' adherence to statin treatment in a period of two years after discharge was analysed. Patients were considered adherent when in possession of medication ≥ 80% of the period. From the day of admission and at follow-up, cholesterol values and the relative number of patients with a total-cholesterol < 4.5 mmol/l were calculated.<br />Results: A significant improvement in statin adherence was noted: 42% versus 75% (p < 0.0001). The most significant difference was observed in patients ≥ 80 years, who improved from 25% to 72% (p < 0.0001). Furthermore, an overall significant reduction in follow-up cholesterol levels was observed: from 4.4 to 4.2 mmol/l (p = 0.003). More-over, an increase was observed in the proportion of patients with a follow-up cholesterol value < 4.5 mmol/l: from 57% to 67% (p = 0.001). The most significant changes were demonstrated in patients ≥ 70 years.<br />Conclusion: Over the five-year period from 2003 to 2008, statin adherence and cholesterol values significantly improved. However, room for improvement remains, particularly in younger patients.<br />Funding: not relevant.<br />Trial Registration: not relevant.
- Subjects :
- Aged
Aged, 80 and over
Cholesterol blood
Denmark
Drug Prescriptions statistics & numerical data
Female
Humans
Hypercholesterolemia blood
Hypercholesterolemia complications
Male
Middle Aged
Myocardial Infarction etiology
Retrospective Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use
Hypercholesterolemia drug therapy
Medication Adherence statistics & numerical data
Myocardial Infarction prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 2245-1919
- Volume :
- 59
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Danish medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 22951203