Late recurrence of sigmoid carcinoma mimicking primary vulvar cancer: case report and review of the literature.

Authors :: Pabuccu E
Tolunay HE
Kocbulut E
Taskın S
Ortac F
Sertcelik A
Sasmaz A
Savas B
Source :: International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2012; Vol. 5 (6), pp. 609-13. Date of Electronic Publication: 2012 Jul 29.
Publication Year :: 2012
Abstract: Objective: To demonstrate a unique case report about late and isolated vulvar metastasis of sigmoid adeno-carcinoma with review of the literature.<br />Material-Method: 57 year old postmenopausal patient with prior sigmoid colon cancer history was admitted with isolated vulvar mass. Immunohistochemistry (IHC) and KRAS gen mutation analysis following surgery were performed to discriminate the metastasis from a vulvar primary malignancy. Further imaging techniques were also performed to exclude additional tumours.<br />Results: Immunohistochemistry (IHC) and KRAS gene mutation analysis revealed isolated metastasis of the colonic adeno-carcinoma in the vulva.<br />Conclusion: Isolated and late occurring vulvar metastasis of colonic origin is very unusual. Careful evaluation and IHC is useful for such cases.

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