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Association between transfusion with human herpesvirus 8 antibody-positive blood and subsequent mortality.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2012 Nov 15; Vol. 206 (10), pp. 1497-503. Date of Electronic Publication: 2012 Sep 04. - Publication Year :
- 2012
-
Abstract
- Background: Human herpesvirus 8 (HHV-8) is endemic in Uganda and transmissible by blood. We evaluated mortality following transfusion of HHV-8 antibody-positive blood.<br />Methods: In a hospital-based, observational, prospective cohort study with a 6-month follow-up, we examined the effect of HHV-8 antibody-positive blood on transfusion recipients surviving at least 7 days.<br />Results: Of 1092 recipients, 471 (43.1%) were transfused with HHV-8 antibody-positive blood. Median age was 1.8 years (range, 0.1-78); 111 (10.2%) died during follow-up. After adjusting for confounders (increasing age, human immunodeficiency virus infection, illness other than malaria, receipt of multiple transfusions), recipients of HHV-8 antibody-positive blood stored ≤4 days ("short-stored") were more likely to die than recipients of HHV-8 antibody-negative blood (adjusted hazards ratio [AHR], 1.92; 95% confidence interval [CI], 1.21-3.05; P = .01). The AHR of the effect of each additional short-stored HHV-8 antibody-positive transfusion was 1.79 (95% CI, 1.33-2.41; P = .001).<br />Conclusions: Transfusion with short-stored HHV-8 antibody-positive blood was associated with an increased risk of death. Further research is warranted to determine if a causal pathway exists and to verify the observed association between acute HHV-8 infection and premature mortality.
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Cohort Studies
Female
HIV Infections complications
Herpesviridae Infections immunology
Humans
Infant
Male
Middle Aged
Risk Factors
Uganda epidemiology
Young Adult
Antibodies, Viral blood
Herpesviridae Infections mortality
Herpesviridae Infections transmission
Herpesvirus 8, Human immunology
Transfusion Reaction
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 206
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22949307
- Full Text :
- https://doi.org/10.1093/infdis/jis543