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Critical issues on high-dose chemotherapy with autologous hematopoietic progenitor cell transplantation in breast cancer patients.
- Source :
-
Expert opinion on biological therapy [Expert Opin Biol Ther] 2012 Nov; Vol. 12 (11), pp. 1505-15. Date of Electronic Publication: 2012 Sep 04. - Publication Year :
- 2012
-
Abstract
- Introduction: High-dose chemotherapy (HDC) with autologous hematopoietic progenitor cell transplantation (AHPCT) for high-risk (HR) or metastatic breast cancer (MBC) is no longer an option.<br />Areas Covered: An expert panel including medical oncologists and hematologists produce an opinion paper on the use of HDC and AHPCT in BC patients and they explain why they believe that; despite inconclusive results thus far, this treatment should have an ongoing role in breast cancer management under clinical trials.<br />Expert Opinion: HDC with AHPCT has become a safe treatment modality and an advantage in disease-free survival has been observed in most of the studies with HDC, with the caveat that today, even a limited relapse-free survival and progression-free survival benefit is sufficient for the approval of new antineoplastic agents. Moreover, in HRBC, an overall survival benefit by HDC could be achieved in the HER2-ve and triple-negative populations and, in this setting, HDC with AHPCT represents a therapeutic option that can be proposed to well-informed patients. In MBC, the HDC approach should be investigated further in selected patients with HER2-ve, chemosensitive disease. This paper is not intended to give any conclusion, but rather to open a debate on the value of HDC in HR and MBC.
- Subjects :
- Animals
Antineoplastic Agents administration & dosage
Breast Neoplasms diagnosis
Breast Neoplasms mortality
Combined Modality Therapy methods
Disease-Free Survival
Dose-Response Relationship, Drug
Female
Hematopoietic Stem Cell Transplantation mortality
Humans
Randomized Controlled Trials as Topic trends
Transplantation, Autologous methods
Transplantation, Autologous mortality
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Breast Neoplasms therapy
Hematopoietic Stem Cell Transplantation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7682
- Volume :
- 12
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Expert opinion on biological therapy
- Publication Type :
- Academic Journal
- Accession number :
- 22946512
- Full Text :
- https://doi.org/10.1517/14712598.2012.721767