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Chemistry and bioactivity of an artificial adenosylpeptide B(12) cofactor.
- Source :
-
Chembiochem : a European journal of chemical biology [Chembiochem] 2012 Sep 24; Vol. 13 (14), pp. 2052-5. Date of Electronic Publication: 2012 Aug 24. - Publication Year :
- 2012
-
Abstract
- Artificial influence: We describe a semi-artificial adenosylpeptide B(12) that behaves as a cofactor in B(12)-dependent enzymatic reactions and demonstrate that the peptide backbone influences its chemical properties and modulates its bioactivity in vitro and in vivo. Inhibition of the growth of L. delbrueckii is demonstrated, thus providing a potentially powerful approach for the development of antibacterial and antiproliferative compounds.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Biomimetic Materials metabolism
Clostridium drug effects
Clostridium enzymology
Coenzymes chemistry
Coenzymes metabolism
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Hydrogen-Ion Concentration
Intramolecular Transferases antagonists & inhibitors
Intramolecular Transferases metabolism
Kinetics
Lactobacillus delbrueckii drug effects
Peptides metabolism
Temperature
Biomimetic Materials chemistry
Peptides chemistry
Vitamin B 12 chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7633
- Volume :
- 13
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Chembiochem : a European journal of chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 22927110
- Full Text :
- https://doi.org/10.1002/cbic.201200429