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Breast cancer in South East Asia: comparison of presentation and outcome between a middle income and a high income country.
- Source :
-
World journal of surgery [World J Surg] 2012 Dec; Vol. 36 (12), pp. 2838-46. - Publication Year :
- 2012
-
Abstract
- Background: There are large differences in socio-economic growth within the region of South East Asia, leading to sharp contrasts in health-systems development between countries. This study compares breast cancer presentation and outcome between patients from a high income country (Singapore) and a middle income country (Malaysia) in South East Asia.<br />Methods: Within the Singapore Malaysia Breast Cancer Registry we identified all consecutive patients diagnosed with breast cancer between 1993 and 2007 at the National University Hospital in Singapore (high income country, n=2,141) and the University of Malaya Medical Center in Kuala Lumpur, Malaysia (middle income country, n=3,320). We compared demographics, tumor characteristics, treatment patterns, and survival between patients from both countries.<br />Results: In Malaysia, patients were less often diagnosed with in situ breast cancer (adjusted odds ratio [ORadj] 0.2; 95% confidence interval [95% CI] 0.1-0.3), more likely to be diagnosed with late stage (III and IV) disease (ORadj for stage III 1.6; 95% CI 1.3-2.0; ORadj for stage IV 1.2; 95% CI 1.1-1.4) as compared to patients from Singapore. Univariate analysis showed that Malaysian patients were at a 72% increased risk of death as compared to Singaporeans. After adjusting for other prognostic factors, the risk decreased by only 5% (ORadj 1.67, 95% CI 1.44-1.92).<br />Conclusions: Differences in way of presentation (except stage and tumor size) and treatment of breast cancer patients from the two countries are small. The overall survival of breast cancer patients from Malaysia is much lower than that of Singaporean patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
Combined Modality Therapy statistics & numerical data
Early Detection of Cancer statistics & numerical data
Female
Follow-Up Studies
Humans
Logistic Models
Malaysia epidemiology
Mastectomy methods
Mastectomy statistics & numerical data
Middle Aged
Prognosis
Registries
Singapore epidemiology
Survival Analysis
Treatment Outcome
Breast Neoplasms diagnosis
Breast Neoplasms mortality
Breast Neoplasms therapy
Developed Countries
Developing Countries
Health Status Disparities
Healthcare Disparities statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2323
- Volume :
- 36
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- World journal of surgery
- Publication Type :
- Academic Journal
- Accession number :
- 22926282
- Full Text :
- https://doi.org/10.1007/s00268-012-1746-2