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Eimeria bovis: an update on parasite-host cell interactions.
- Source :
-
International journal of medical microbiology : IJMM [Int J Med Microbiol] 2012 Oct; Vol. 302 (4-5), pp. 210-5. Date of Electronic Publication: 2012 Aug 25. - Publication Year :
- 2012
-
Abstract
- Apicomplexan parasites are obligate intracellular protozoans and are well recognized modulators of the host cell machinery on varying levels such as host cell metabolism, MHC expression, cell cycle, or apoptosis in order to guarantee their intracellular development and survival. One of the most thoroughly examined apicomplexan pathogens demonstrating a potent manipulative capacity with respect to various host cell functions is Toxoplasma gondii, a protozoon exhibiting rapid intracellular development with small meronts in any nucleated cell, almost irrespective of the cell type or host origin. In contrast, Eimeria bovis merogony I is host- and cell type-restricted and occurs exclusively in bovine endothelial host cells. Furthermore, as a peculiarity, intracellular E. bovis meront I development is a long-lasting process (up to 3 weeks), leading to the formation of huge macromeronts of up to 300 μm in size, containing up to 120,000 merozoites I as offspring. In consequence, the necessity for intense host cell modulation to support this particular development appears even more pressing than in other apicomplexan parasite cases. Here we review the data currently available on E. bovis-host cell interactions, indicating the intriguing capacity of this protozoan to exploit and utilize its host cell for its own benefit.<br /> (Copyright © 2012 Elsevier GmbH. All rights reserved.)
- Subjects :
- Animals
Apoptosis
Cattle
Cell Shape
Coccidiosis immunology
Coccidiosis parasitology
Cytoskeleton metabolism
Cytoskeleton parasitology
Eimeria genetics
Eimeria immunology
Eimeria metabolism
Endothelial Cells immunology
Endothelial Cells metabolism
Gene Expression Regulation
Species Specificity
Sporozoites metabolism
Transcription, Genetic
Eimeria pathogenicity
Endothelial Cells parasitology
Host-Parasite Interactions
Sporozoites growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0607
- Volume :
- 302
- Issue :
- 4-5
- Database :
- MEDLINE
- Journal :
- International journal of medical microbiology : IJMM
- Publication Type :
- Academic Journal
- Accession number :
- 22925990
- Full Text :
- https://doi.org/10.1016/j.ijmm.2012.07.002