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Copper-catalyzed desymmetric intramolecular Ullmann C-N coupling: an enantioselective preparation of indolines.
- Source :
-
Journal of the American Chemical Society [J Am Chem Soc] 2012 Sep 05; Vol. 134 (35), pp. 14326-9. Date of Electronic Publication: 2012 Aug 24. - Publication Year :
- 2012
-
Abstract
- The first highly enantioselective copper-catalyzed intramolecular Ullmann C-N coupling reaction has been developed. The asymmetric desymmetrization of 1,3-bis(2-iodoaryl)propan-2-amines catalyzed by CuI/(R)-BINOL-derived ligands led to the enantioselective formation of indolines in high yields and excellent enantiomeric excesses. This method was also applied to the formation of 1,2,3,4-tetrahydroquinolines in high yields and excellent enantioselectivity.
Details
- Language :
- English
- ISSN :
- 1520-5126
- Volume :
- 134
- Issue :
- 35
- Database :
- MEDLINE
- Journal :
- Journal of the American Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 22913611
- Full Text :
- https://doi.org/10.1021/ja306631z