miRNA and tropism of human parvovirus B19.

Authors :: Berillo O
Khailenko V
Ivashchenko A
Perlmuter-Shoshany L
Bolshoy A
Source :: Computational biology and chemistry [Comput Biol Chem] 2012 Oct; Vol. 40, pp. 1-6. Date of Electronic Publication: 2012 Jul 31.
Publication Year :: 2012
Abstract: Parvovirus B19 has an extreme tropism for human erythroid progenitors. Here we propose the hypothesis explaining the tropism of human parvovirus B19. Our speculations are based on experimental results related to the capsid proteins VP1 and VP2. These proteins were not detectable in nonpermissive cells in course of these experiments, although the corresponding mRNAs were synthesized. Our interpretation of these results is an inhibition of translation in nonpermissive cells by human miRNAs. We bring support to our hypothesis and propose detailed experimental procedure to test it.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)