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Lithospermum erythrorhizon suppresses high-fat diet-induced obesity, and acetylshikonin, a main compound of Lithospermum erythrorhizon, inhibits adipocyte differentiation.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2012 Sep 12; Vol. 60 (36), pp. 9089-96. Date of Electronic Publication: 2012 Aug 27. - Publication Year :
- 2012
-
Abstract
- Lithospermum erythrorhizon, which has traditionally been used as a vegetable and to make the liquor Jindo Hongju, contains several naphthoquinone pigments, including shikonin. This study aimed to evaluate the antiobesity effects of Lithospermum erythrorhizon ethanol extract (LE) and elucidate the underlying mechanism. C57BL/6J mice were fed a normal or high-fat diet with or without LE supplementation for 8 weeks. LE reduced high-fat diet-induced increases in body weight, white adipose tissue mass, serum triglyceride and total cholesterol levels, and hepatic lipid levels while decreasing lipogenic and adipogenic gene expression. Furthermore, acetylshikonin suppressed adipocyte differentiation in a dose-dependent manner and significantly attenuated adipogenic transcription factor expression in 3T3-L1 cells. These findings suggest that Lithospermum erythrorhizon prevents obesity by inhibiting adipogenesis through downregulation of genes involved in the adipogenesis pathway and may be a useful dietary supplement for the prevention of obesity.
- Subjects :
- Adipocytes drug effects
Adipocytes metabolism
Animals
Diet, High-Fat adverse effects
Down-Regulation drug effects
Humans
Male
Obesity genetics
Obesity metabolism
Obesity physiopathology
Rats
Rats, Sprague-Dawley
Adipocytes cytology
Anthraquinones administration & dosage
Anti-Obesity Agents administration & dosage
Cell Differentiation drug effects
Lithospermum chemistry
Obesity drug therapy
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 60
- Issue :
- 36
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22900585
- Full Text :
- https://doi.org/10.1021/jf3017404