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An integrated model for the nucleo-cytoplasmic transport of cytoplasmic poly(A)-binding proteins.
- Source :
-
Communicative & integrative biology [Commun Integr Biol] 2012 May 01; Vol. 5 (3), pp. 243-7. - Publication Year :
- 2012
-
Abstract
- Cytoplasmic poly(A)-binding proteins (PABPs) regulate mRNA stability and translation. Although predominantly localized in the cytoplasm, PABP proteins also cycle through the nucleus. Recent work has established that their steady-state localization can be altered by cellular stresses such as ultraviolet (UV) radiation, and infection by several viruses, resulting in nuclear accumulation of PABPs. Here, we present further evidence that their interaction with and release from mRNA and translation complexes are important in determining their sub-cellular distribution and propose an integrated model for regulated nucleo-cytoplasmic transport of PABPs.
Details
- Language :
- English
- ISSN :
- 1942-0889
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Communicative & integrative biology
- Publication Type :
- Academic Journal
- Accession number :
- 22896784
- Full Text :
- https://doi.org/10.4161/cib.19347