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The effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation in migraine prophylaxis.
- Source :
-
Biological trace element research [Biol Trace Elem Res] 2012 Dec; Vol. 150 (1-3), pp. 42-8. Date of Electronic Publication: 2012 Aug 17. - Publication Year :
- 2012
-
Abstract
- Given the conflicting results about the positive effects of magnesium and L-carnitine and as there is no report concerning concurrent supplementation of magnesium and L-carnitine on migraine prophylaxis, the effects of magnesium, L-carnitine, and concurrent magnesium-L-carnitine supplementation on migraine indicators were assessed. In this clinical trial, 133 migrainous patients were randomly assigned into three intervention groups: magnesium oxide (500 mg/day), L-carnitine (500 mg/day), and Mg-L-carnitine (500 mg/day magnesium and 500 mg/day L-carnitine), and a control group. After 12 weeks of supplementation, the checklist of migraine indicators including migraine attacks/month, migraine days/month, and headache severity was completed, and serum concentrations of magnesium and L-carnitine were measured by atomic absorption spectrophotometry and enzymatic UV test, respectively. The results showed a significant reduction in all migraine indicators in all studied groups (p < 0.05). The ANOVA results showed a significant reduction in migraine frequency across various supplemented and control groups (p = 0.008). By separating the effects of magnesium supplementation from other confounding factors such as routine treatments using the repeated measures and nested model, it was clarified that magnesium supplementation had a significant effect on all migraine indicators. Oral supplementation with magnesium oxide and L-carnitine and concurrent supplementation of Mg-L-carnitine besides routine treatments could be effective in migraine prophylaxis; however, larger trials are needed to confirm these preliminary findings.
- Subjects :
- Adult
Carnitine blood
Female
Humans
Magnesium blood
Magnesium Oxide administration & dosage
Male
Migraine Disorders blood
Migraine Disorders diet therapy
Migraine Disorders physiopathology
Secondary Prevention
Severity of Illness Index
Single-Blind Method
Spectrophotometry, Atomic
Young Adult
Carnitine therapeutic use
Dietary Supplements
Magnesium therapeutic use
Migraine Disorders prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1559-0720
- Volume :
- 150
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- Biological trace element research
- Publication Type :
- Academic Journal
- Accession number :
- 22895810
- Full Text :
- https://doi.org/10.1007/s12011-012-9487-5