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An aquatic host-guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2012 Oct 07; Vol. 10 (37), pp. 7562-5. - Publication Year :
- 2012
-
Abstract
- We describe the synthesis of a fluorescent deoxyguanosine derivative that co-assembles (in water) with an unlabeled analogue into a heteromeric supramolecular G-quadruplex, which forms a host-guest complex with doxorubicin as evidenced by FRET experiments.
- Subjects :
- Deoxyguanosine analogs & derivatives
Deoxyguanosine chemical synthesis
Deoxyguanosine chemistry
Fluorescence Resonance Energy Transfer
Fluorescent Dyes chemical synthesis
Fluorescent Dyes chemistry
Macromolecular Substances chemistry
Models, Molecular
Molecular Structure
Temperature
Water chemistry
Antineoplastic Agents chemistry
Doxorubicin chemistry
G-Quadruplexes
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0539
- Volume :
- 10
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22895684
- Full Text :
- https://doi.org/10.1039/c2ob25913c