Back to Search
Start Over
Deoxycalyciphylline B, a hepatotoxic alkaloid from Daphniphyllum calycinum.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2012 Aug 13; Vol. 17 (8), pp. 9641-51. Date of Electronic Publication: 2012 Aug 13. - Publication Year :
- 2012
-
Abstract
- Daphniphyllum calycinum (DC), a main component of Chinese patent drug Fengliao-Changweikang, is effectively used to cure bowel disease in the clinic. It was recorded that DC possessed slight toxicity, which was caused by the alkaloids existing in its extract. Unfortunately, to date the toxicity level and toxic constituents are still unclear. The present study is designed to illustrate the acute toxicity and induced organ damages of the total alkaloids as well as to determine the toxic constituents. Based on the above studies, not only was the acute toxicity determined but also hepatic toxicity was characterized by increased plasma biomarkers of ALT and AST and liver cell inflammatory infiltrate as well necrosis that was firstly observed. Significantly, deoxycalyciphylline B exhibited exactly the same hepatic toxicity so it was identified as the main toxic constituent in DC. An obvious dose-effect relationship between the toxic compound and induced hepatic injuries was also observed. Moreover, the Chinese patent drug Fengliao-Changweikang contained low levels of the toxic compound, compared with the total alkaloids. Therefore, this Chinese patent drug could be regarded to be safe in this point of view.
- Subjects :
- Alanine Transaminase blood
Alkaloids administration & dosage
Alkaloids chemistry
Animals
Aspartate Aminotransferases blood
Behavior, Animal drug effects
Chemical and Drug Induced Liver Injury blood
Drugs, Chinese Herbal adverse effects
Heterocyclic Compounds, 4 or More Rings administration & dosage
Heterocyclic Compounds, 4 or More Rings chemistry
Male
Mice
Alkaloids toxicity
Chemical and Drug Induced Liver Injury pathology
Drugs, Chinese Herbal chemistry
Ferns chemistry
Heterocyclic Compounds, 4 or More Rings toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 17
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 22890169
- Full Text :
- https://doi.org/10.3390/molecules17089641