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Facile graft of poly(2-methacryloyloxyethyl phosphorylcholine) onto Fe(3) O(4) nanoparticles by ATRP: synthesis, properties, and biocompatibility.

Authors :
Sun XY
Yu SS
Wan JQ
Chen KZ
Source :
Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2013 Feb; Vol. 101 (2), pp. 607-12. Date of Electronic Publication: 2012 Aug 10.
Publication Year :
2013

Abstract

Magnetite (Fe(3) O(4) ) nanoparticles with the surface hydroxyl groups were achieved by a polyol process. Using 2-(4-chlorosulfonylphenyl) ethyltrichlorosilane (CTCS) as initiator, 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) as monomer, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-grafted Fe(3) O(4) nanoparticles (MNP) were successfully prepared via the atom transfer radical polymerization (ATRP) method. The successful grafting of PMPC on the Fe(3) O(4) nanoparticles surface was ascertained from the FTIR analysis. The modified nanoparticles (MNP-CTCS-PMPC) showed a good biocompatibility in the cytotoxicity test in vitro. Performance testing of MNP-CTCS-PMPC was performed through magnetic resonance analysis (MR), and its r(2) /r(1) value was 24.1. These results indicated that the modified Fe(3) O(4) nanoparticles would be a potential MRI contrast reagent.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1552-4965
Volume :
101
Issue :
2
Database :
MEDLINE
Journal :
Journal of biomedical materials research. Part A
Publication Type :
Academic Journal
Accession number :
22887925
Full Text :
https://doi.org/10.1002/jbm.a.34343