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Facile graft of poly(2-methacryloyloxyethyl phosphorylcholine) onto Fe(3) O(4) nanoparticles by ATRP: synthesis, properties, and biocompatibility.
- Source :
-
Journal of biomedical materials research. Part A [J Biomed Mater Res A] 2013 Feb; Vol. 101 (2), pp. 607-12. Date of Electronic Publication: 2012 Aug 10. - Publication Year :
- 2013
-
Abstract
- Magnetite (Fe(3) O(4) ) nanoparticles with the surface hydroxyl groups were achieved by a polyol process. Using 2-(4-chlorosulfonylphenyl) ethyltrichlorosilane (CTCS) as initiator, 2-(methacryloyloxy)ethyl phosphorylcholine (MPC) as monomer, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC)-grafted Fe(3) O(4) nanoparticles (MNP) were successfully prepared via the atom transfer radical polymerization (ATRP) method. The successful grafting of PMPC on the Fe(3) O(4) nanoparticles surface was ascertained from the FTIR analysis. The modified nanoparticles (MNP-CTCS-PMPC) showed a good biocompatibility in the cytotoxicity test in vitro. Performance testing of MNP-CTCS-PMPC was performed through magnetic resonance analysis (MR), and its r(2) /r(1) value was 24.1. These results indicated that the modified Fe(3) O(4) nanoparticles would be a potential MRI contrast reagent.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)
- Subjects :
- HeLa Cells
Humans
Magnetic Resonance Spectroscopy
Nanoparticles ultrastructure
Phosphorylcholine chemical synthesis
Phosphorylcholine chemistry
Polymethacrylic Acids
Silanes chemistry
Spectroscopy, Fourier Transform Infrared
Thermogravimetry
X-Ray Diffraction
Ferric Compounds chemical synthesis
Ferric Compounds chemistry
Materials Testing
Methacrylates chemical synthesis
Methacrylates chemistry
Nanoparticles chemistry
Phosphorylcholine analogs & derivatives
Polymerization
Subjects
Details
- Language :
- English
- ISSN :
- 1552-4965
- Volume :
- 101
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of biomedical materials research. Part A
- Publication Type :
- Academic Journal
- Accession number :
- 22887925
- Full Text :
- https://doi.org/10.1002/jbm.a.34343