Interleukin-1 beta gene polymorphisms and preterm birth.

Authors :: Schmid M
Haslinger P
Stary S
Leipold H
Egarter C
Grimm C
Source :: European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2012 Nov; Vol. 165 (1), pp. 33-6. Date of Electronic Publication: 2012 Aug 11.
Publication Year :: 2012
Abstract: Objective: To investigate the association between two genetic variations in the Interleukin-1 beta (IL1B) gene and preterm birth.<br />Study Design: In this case-control study we tested the allelic distribution of two of its common polymorphisms (IL1B +3953C>T [rs1143634], IL1B -511C>T [rs16944]) in one hundred women with preterm birth and one hundred healthy women with at least one uncomplicated full term pregnancy and no history of preterm birth.<br />Results: A significant association was found between the presence of the IL1B +3953C>T polymorphism and preterm birth (p=0.049, OR 0.6 [0.3-1.0]). No significant association was found between the IL1B -511C>T polymorphism and preterm birth (p=0.471, OR 1.3 [0.7-2.3]).<br />Conclusion: Our findings suggest that the IL1B +3953C>T polymorphism is associated with a risk reduction for preterm birth in Caucasian women, possibly by altering the inflammatory response during pregnancy.<br /> (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Language :: English
ISSN :: 1872-7654
Volume :: 165
Issue :: 1
Database :: MEDLINE
Journal :: European journal of obstetrics, gynecology, and reproductive biology
Publication Type :: Academic Journal
Accession number :: 22884587
Full Text :: https://doi.org/10.1016/j.ejogrb.2012.07.013