Back to Search
Start Over
[Relationship between B/C genotype of hepatitis B virus and hepatitis B virus related-nephritis in children].
- Source :
-
Zhonghua er ke za zhi = Chinese journal of pediatrics [Zhonghua Er Ke Za Zhi] 2012 May; Vol. 50 (5), pp. 376-9. - Publication Year :
- 2012
-
Abstract
- Objective: To investigate the relationship between genotype of hepatitis B virus and hepatitis B virus related-glomerular nephritis in (HBV-GN) children.<br />Method: Totally 176 HBV-DNA positive children with chronic hepatitis B were randomly collected. Among the 176 patients, 92 were HBV carriers, 84 were cases with chronic hepatitis. The genotypes of their serum HBV, liver function, and HBV-DNA load were detected. When children showed nephrotic syndrome, renal biopsy was performed.<br />Result: Of the serum samples of 176 cases, 85 (48.3%) were genotype C, 72 (40.9%) were genotype B, 13 (7.4%) were genotype B/C, and 6 (3.4%) were non-B/C genotype which were excluded. Among the analyzed 157 cases, the ratio of HBV-GN in the HBeAg positive group (78.3%) was significantly higher than that in the negative group (21.7%) (χ(2) = 18.301, P < 0.001). And, the ratio of HBV-GN in the genotype C group (73.9%) was significantly higher than that in the genotype B group (26.1%) (P < 0.039). The ratio of hematuria or proteinuria in the genotype C group (20%, 18.8%) was significantly higher than that in the genotype B group (8.3%, 5.6%) (P < 0.039; P value = 0.013); and the alteration of ALT or C3 in the genotype C group (10.2%, 15.3%) was more frequent than those in the genotype B group (2.8%, 2.8%) (P = 0.005; P = 0.008). There were no significant differences in kidney dysfunction or hepatomegaly. Further, the ratio of HBV-GN was more significantly frequent in HBV-DNA highly loading group (79.2%) than which in HBV-DNA lowly loading group (20.8%) (P = 0.000). Finally, in HBV-GN group, genotype C cases (88.2%) more frequently had high HBV-DNA load condition than genotype B cases (11.8%) (P = 0.021).<br />Conclusion: Children with HBV infection in Gansu province showed mainly genotypes C or B, while genotype C seemingly predominant. Patients with genotype C more frequently showed proteinuria or hematuria. The high HBV-DNA load may be related with HBV-GN. It is a potential reason in the mechanism of HBV-GN that patients with genotype C had more possibility to have HBV-DNA high load. Analysis of HBV genotype for HBV patients maybe helpful in diagnosis and treatment.
- Subjects :
- Adolescent
Biopsy, Needle
Child
Child, Preschool
China epidemiology
DNA, Viral blood
DNA, Viral genetics
Female
Genotype
Hepatitis B blood
Hepatitis B epidemiology
Humans
Infant
Male
Nephritis pathology
Viral Load
Hepatitis B virology
Hepatitis B virus genetics
Nephritis epidemiology
Nephritis virology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0578-1310
- Volume :
- 50
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Zhonghua er ke za zhi = Chinese journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 22883042