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Prognostic value of right ventricular longitudinal peak systolic strain in patients with pulmonary hypertension.
- Source :
-
Circulation. Cardiovascular imaging [Circ Cardiovasc Imaging] 2012 Sep 01; Vol. 5 (5), pp. 628-36. Date of Electronic Publication: 2012 Aug 08. - Publication Year :
- 2012
-
Abstract
- Background: Right ventricular (RV) function is an important prognostic marker in patients with pulmonary hypertension. The present evaluation assessed the prognostic value of RV longitudinal peak systolic strain (LPSS) in patients with pulmonary hypertension.<br />Methods and Results: A total of 150 patients with pulmonary hypertension of different etiologies (mean age, 59±15 years; 37.3% male) were evaluated. RV fractional area change and tricuspid annular plane systolic excursion index were evaluated with 2-dimensional echocardiography. RV LPSS was assessed with speckle-tracking echocardiography. The patient population was categorized according to a RV LPSS value of -19%. Among several clinical and echocardiographic parameters, the significant determinants of all-cause mortality were evaluated. There were no significant differences in age, sex, pulmonary hypertension cause and left ventricular ejection fraction between patients with RV LPSS <-19% and patients with RV LPSS ≥-19%. However, patients with RV LPSS ≥-19% had significantly worse New York Heart Association functional class (2.7±0.6 versus 2.3±0.8; P=0.003) and lower tricuspid annular plane systolic excursion (16±4 mm versus 18±3 mm; P<0.001) than their counterparts. During a median follow-up of 2.6 years, 37 patients died. RV LPSS was a significant determinant of all-cause mortality (HR, 3.40; 95% CI, 1.19-9.72; P=0.02).<br />Conclusions: In patients with pulmonary hypertension, RV LPSS is significantly associated with all-cause mortality. RV LPSS may be a valuable parameter for risk stratification of these patients. Future studies are needed to confirm these results in the pulmonary hypertension subgroups.
- Subjects :
- Adult
Aged
Chi-Square Distribution
Disease Progression
Echocardiography, Doppler
Female
Humans
Hypertension, Pulmonary diagnostic imaging
Hypertension, Pulmonary mortality
Kaplan-Meier Estimate
Male
Middle Aged
Netherlands
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Retrospective Studies
Risk Assessment
Risk Factors
Hypertension, Pulmonary physiopathology
Systole
Ventricular Function, Right
Subjects
Details
- Language :
- English
- ISSN :
- 1942-0080
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Circulation. Cardiovascular imaging
- Publication Type :
- Academic Journal
- Accession number :
- 22875884
- Full Text :
- https://doi.org/10.1161/CIRCIMAGING.111.971465