Back to Search
Start Over
Increased blood-cerebrospinal fluid transfer of albumin in advanced Parkinson's disease.
- Source :
-
Journal of neuroinflammation [J Neuroinflammation] 2012 Aug 08; Vol. 9, pp. 188. Date of Electronic Publication: 2012 Aug 08. - Publication Year :
- 2012
-
Abstract
- Background: Alterations in blood-brain barrier permeability have been proposed to represent a relevant factor contributing to Parkinson's disease progression. However, few studies have addressed this issue in patients at different stages of disease.<br />Methods: Albumin was measured in cerebrospinal fluid and serum samples obtained from 73 non-demented subjects with idiopathic Parkinson's disease and 47 age-matched control subjects. The albumin ratio (AR) was calculated to assess blood-cerebrospinal fluid and blood-brain barrier function. The group of patients with Parkinson's disease included 46 subjects with Hoehn-Yahr staging between 1 and 2 and 27, with a score ranging from 2.5 to 4.<br />Results: Statistically significant differences in albumin ratio were found between patients with advanced disease, and both early-stage and unaffected groups. Conversely, early-phase patients did not differ from healthy subjects. Additionally, dopaminergic treatment seems to exert a possible effect on AR values.<br />Conclusions: Our study demonstrates that possible dysfunction of the blood-cerebrospinal fluid barrier, blood-brain barrier, or both, characterize Parkinson's disease progression. The associations between clinical scores, treatments and biochemical findings suggest a progressive impairment of barrier integrity during the course of the disease.
- Subjects :
- Adult
Aged
Aged, 80 and over
Albumins metabolism
Biomarkers blood
Biomarkers cerebrospinal fluid
Cohort Studies
Female
Humans
Male
Middle Aged
Parkinson Disease pathology
Albumins biosynthesis
Albumins cerebrospinal fluid
Blood-Brain Barrier metabolism
Parkinson Disease blood
Parkinson Disease cerebrospinal fluid
Severity of Illness Index
Subjects
Details
- Language :
- English
- ISSN :
- 1742-2094
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of neuroinflammation
- Publication Type :
- Academic Journal
- Accession number :
- 22870899
- Full Text :
- https://doi.org/10.1186/1742-2094-9-188