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Analysis of association between the MUC4 g.8227C>G polymorphism and production traits in Italian heavy pigs using a selective genotyping approach.
- Source :
-
Animal biotechnology [Anim Biotechnol] 2012; Vol. 23 (3), pp. 147-55. - Publication Year :
- 2012
-
Abstract
- In pigs, susceptibility to enterotoxigenic Escherichia coli (ETEC) K88 strains (locus F4bcR) is determined by a dominant allele, with the recessive allele determining resistance. The susceptible allele also appeared to be associated with higher growth rate even with discordant results. A single nucleotide polymorphism (SNP) in exon 7 of the mucin 4 (MUC4) gene (DQ848681:g.8227C>G), shown to be in close linkage disequilibrium with the F4bcR locus, has been used as marker to identify susceptible pigs, substituting invasive villous adhesion tests. We herein analyzed this SNP in Italian local breeds and applied a selective genotyping approach in Italian Large White, Italian Landrace, and Italian Duroc comparing allele frequency distribution in groups of pigs with extreme estimated breeding values (EBV) for average daily gain (ADG) and backfat thickness (BFT) to evaluate if this marker is associated with these traits. Allele G (associated with susceptibility to ETEC) was associated with higher ADG and BFT in Italian Large White (P=6.66E-04 and P=0.012, respectively) and higher ADG in Italian Landrace (P=7.23E-12). This polymorphism was poorly informative in Italian Duroc. Antagonistic associations of the MUC4 g.8227C>G alleles on susceptibility to ETEC and growth performances evidence the complexity of applying marker assisted selection in pig breeding.
- Subjects :
- Animals
Base Sequence
Biotechnology
Breeding
DNA Primers genetics
Enterotoxigenic Escherichia coli pathogenicity
Escherichia coli Infections genetics
Escherichia coli Infections microbiology
Escherichia coli Infections veterinary
Female
Gene Frequency
Genotyping Techniques
Italy
Linkage Disequilibrium
Polymorphism, Single Nucleotide
Receptors, Immunologic genetics
Sus scrofa microbiology
Swine
Swine Diseases genetics
Swine Diseases microbiology
Mucin-4 genetics
Sus scrofa genetics
Sus scrofa growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2378
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Animal biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 22870870
- Full Text :
- https://doi.org/10.1080/10495398.2011.653462