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The impact of simple orchiectomy on semen quality and endocrine parameters in postpubertal cryptorchid men.

Authors :
Irkilata HC
Kibar Y
Basal S
Kurt B
Gunal A
Alp BF
Oral E
Musabak U
Tahmaz L
Dayanc M
Source :
International urology and nephrology [Int Urol Nephrol] 2012 Dec; Vol. 44 (6), pp. 1617-22. Date of Electronic Publication: 2012 Aug 05.
Publication Year :
2012

Abstract

Purpose: The main objectives of this retrospective cohort study were to evaluate reproductive endocrine and semen profiles before and after simple orchiectomy in patients with unilateral postpubertal cryptorchidism and to investigate the relationship between hormone levels and histopathology of the removed testis.<br />Methods: We evaluated 40 adult males who were admitted to our clinic, between 2001 and 2007, with unilateral undescended testis. Right orchiectomy was performed in 27 patients and left orchiectomy in 13. Semen analysis, serum inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were examined in before and 3 months after orchiectomy. Orchiectomy materials were evaluated histopathologically.<br />Results: Semen parameters, as well as testosterone and LH levels, did not change in any histopathological subgroups in the postoperative follow-up. In patients with maturation arrest, mean serum inhibin B level statistically significantly decreased from 160.9 to 83.5 pg/ml, and mean FSH level significantly increased from 4.8 to 7.6 mIU/ml after orchiectomy (p value, 0.008 and 0.008, respectively). Though, the levels were still within the normal range of the two hormones.<br />Conclusions: Simple orchiectomy does not have any effect on semen parameters and testosterone level in patients with postpubertal cryptorchidism. The change in inhibin B and FSH levels after orchiectomy in patients with maturation arrest is not clinically significant.

Details

Language :
English
ISSN :
1573-2584
Volume :
44
Issue :
6
Database :
MEDLINE
Journal :
International urology and nephrology
Publication Type :
Academic Journal
Accession number :
22865396
Full Text :
https://doi.org/10.1007/s11255-012-0256-3