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Image registration improves human knee cartilage T1 mapping with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC).
- Source :
-
European radiology [Eur Radiol] 2013 Jan; Vol. 23 (1), pp. 246-52. Date of Electronic Publication: 2012 Aug 04. - Publication Year :
- 2013
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Abstract
- Objectives: To evaluate the effect of automated registration in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of the knee on the occurrence of movement artefacts on the T1 map and the reproducibility of region-of-interest (ROI)-based measurements.<br />Methods: Eleven patients with early-stage knee osteoarthritis and ten healthy controls underwent dGEMRIC twice at 3 T. Controls underwent unenhanced imaging. ROIs were manually drawn on the femoral and tibial cartilage. T1 calculation was performed with and without registration of the T1-weighted images. Automated three-dimensional rigid registration was performed on the femur and tibia cartilage separately. Registration quality was evaluated using the square root Cramér-Rao lower bound (CRLB(σ)). Additionally, the reproducibility of dGEMRIC was assessed by comparing automated registration with manual slice-matching.<br />Results: Automated registration of the T1-weighted images improved the T1 maps as the 90% percentile of the CRLB(σ) was significantly (P < 0.05) reduced with a median reduction of 55.8 ms (patients) and 112.9 ms (controls). Manual matching and automated registration of the re-imaged T1 map gave comparable intraclass correlation coefficients of respectively 0.89/0.90 (patients) and 0.85/0.85 (controls).<br />Conclusions: Registration in dGEMRIC reduces movement artefacts on T1 maps and provides a good alternative to manual slice-matching in longitudinal studies.
- Subjects :
- Artifacts
Case-Control Studies
Contrast Media
Female
Gadolinium DTPA
Humans
Image Enhancement methods
Image Interpretation, Computer-Assisted methods
Male
Middle Aged
Pain Measurement
Reproducibility of Results
Cartilage, Articular pathology
Magnetic Resonance Imaging methods
Osteoarthritis, Knee pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 22865226
- Full Text :
- https://doi.org/10.1007/s00330-012-2590-3