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Image registration improves human knee cartilage T1 mapping with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC).

Authors :
Bron EE
van Tiel J
Smit H
Poot DH
Niessen WJ
Krestin GP
Weinans H
Oei EH
Kotek G
Klein S
Source :
European radiology [Eur Radiol] 2013 Jan; Vol. 23 (1), pp. 246-52. Date of Electronic Publication: 2012 Aug 04.
Publication Year :
2013

Abstract

Objectives: To evaluate the effect of automated registration in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of the knee on the occurrence of movement artefacts on the T1 map and the reproducibility of region-of-interest (ROI)-based measurements.<br />Methods: Eleven patients with early-stage knee osteoarthritis and ten healthy controls underwent dGEMRIC twice at 3 T. Controls underwent unenhanced imaging. ROIs were manually drawn on the femoral and tibial cartilage. T1 calculation was performed with and without registration of the T1-weighted images. Automated three-dimensional rigid registration was performed on the femur and tibia cartilage separately. Registration quality was evaluated using the square root Cramér-Rao lower bound (CRLB(σ)). Additionally, the reproducibility of dGEMRIC was assessed by comparing automated registration with manual slice-matching.<br />Results: Automated registration of the T1-weighted images improved the T1 maps as the 90% percentile of the CRLB(σ) was significantly (P < 0.05) reduced with a median reduction of 55.8 ms (patients) and 112.9 ms (controls). Manual matching and automated registration of the re-imaged T1 map gave comparable intraclass correlation coefficients of respectively 0.89/0.90 (patients) and 0.85/0.85 (controls).<br />Conclusions: Registration in dGEMRIC reduces movement artefacts on T1 maps and provides a good alternative to manual slice-matching in longitudinal studies.

Details

Language :
English
ISSN :
1432-1084
Volume :
23
Issue :
1
Database :
MEDLINE
Journal :
European radiology
Publication Type :
Academic Journal
Accession number :
22865226
Full Text :
https://doi.org/10.1007/s00330-012-2590-3