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Age-related changes in core body temperature and activity in triple-transgenic Alzheimer's disease (3xTgAD) mice.
- Source :
-
Disease models & mechanisms [Dis Model Mech] 2013 Jan; Vol. 6 (1), pp. 160-70. Date of Electronic Publication: 2012 Aug 03. - Publication Year :
- 2013
-
Abstract
- Alzheimer's disease (AD) is characterised, not only by cognitive deficits and neuropathological changes, but also by several non-cognitive behavioural symptoms that can lead to a poorer quality of life. Circadian disturbances in core body temperature and physical activity are reported in AD patients, although the cause and consequences of these changes are unknown. We therefore characterised circadian patterns of body temperature and activity in male triple transgenic AD mice (3xTgAD) and non-transgenic (Non-Tg) control mice by remote radiotelemetry. At 4 months of age, daily temperature rhythms were phase advanced and by 6 months of age an increase in mean core body temperature and amplitude of temperature rhythms were observed in 3xTgAD mice. No differences in daily activity rhythms were seen in 4- to 9-month-old 3xTgAD mice, but by 10 months of age an increase in mean daily activity and the amplitude of activity profiles for 3xTgAD mice were detected. At all ages (4-10 months), 3xTgAD mice exhibited greater food intake compared with Non-Tg mice. The changes in temperature did not appear to be solely due to increased food intake and were not cyclooxygenase dependent because the temperature rise was not abolished by chronic ibuprofen treatment. No β-amyloid (Aβ) plaques or neurofibrillary tangles were noted in the hypothalamus of 3xTgAD mice, a key area involved in temperature regulation, although these pathological features were observed in the hippocampus and amygdala of 3xTgAD mice from 10 months of age. These data demonstrate age-dependent changes in core body temperature and activity in 3xTgAD mice that are present before significant AD-related neuropathology and are analogous to those observed in AD patients. The 3xTgAD mouse might therefore be an appropriate model for studying the underlying mechanisms involved in non-cognitive behavioural changes in AD.
- Subjects :
- Aging physiology
Alzheimer Disease pathology
Alzheimer Disease psychology
Amyloid beta-Protein Precursor genetics
Animals
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Brain pathology
Brain physiopathology
Circadian Rhythm physiology
Disease Models, Animal
Eating physiology
Humans
Hypothalamus pathology
Hypothalamus physiopathology
Ibuprofen pharmacology
Male
Maze Learning drug effects
Maze Learning physiology
Memory drug effects
Memory physiology
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Transgenic
Neurofibrillary Tangles pathology
Presenilin-1 genetics
tau Proteins genetics
tau Proteins metabolism
Alzheimer Disease genetics
Alzheimer Disease physiopathology
Body Temperature physiology
Motor Activity physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1754-8411
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Disease models & mechanisms
- Publication Type :
- Academic Journal
- Accession number :
- 22864021
- Full Text :
- https://doi.org/10.1242/dmm.010173