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Increased frontomotor oscillations during tic suppression in children with Tourette syndrome.
- Source :
-
Journal of child neurology [J Child Neurol] 2013 May; Vol. 28 (5), pp. 615-24. Date of Electronic Publication: 2012 Aug 01. - Publication Year :
- 2013
-
Abstract
- This work investigated whether Tourette syndrome patients exhibit alterations in neural oscillations during spontaneous expression and suppression of tics. Electroencephalograms (EEGs) were recorded from 9 medication-naïve children with Tourette syndrome and 10 age-matched healthy subjects in resting conditions and during tic suppression. Their cortical oscillations were examined using the power spectral method and partial directed coherence. The authors found increased oscillations of broad frequency bands in the frontomotor regions of patients during tic expression, suggesting the involvement of aberrant cortical oscillations in Tourette syndrome. More significantly, prominent increases in theta oscillation in the prefrontal area and directed frontomotor interactions in the theta and beta bands were observed during tic suppression. Furthermore, the directed EEG interaction from the frontal to motor regions was positively correlated with the severity of tic symptoms. These findings suggest that the frontal to motor interaction of cortical oscillations plays a significant role in tic suppression.
- Subjects :
- Beta Rhythm
Brain Mapping
Child
Humans
Male
Neural Pathways physiopathology
Prefrontal Cortex physiopathology
Reference Values
Statistics as Topic
Theta Rhythm
Tourette Syndrome diagnosis
Electroencephalography
Frontal Lobe physiopathology
Inhibition, Psychological
Motor Cortex physiopathology
Signal Processing, Computer-Assisted
Tourette Syndrome physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1708-8283
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of child neurology
- Publication Type :
- Academic Journal
- Accession number :
- 22859696
- Full Text :
- https://doi.org/10.1177/0883073812450317