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Development, characterization and efficacy of niosomal diallyl disulfide in treatment of disseminated murine candidiasis.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2013 Feb; Vol. 9 (2), pp. 247-56. Date of Electronic Publication: 2012 Jul 31. - Publication Year :
- 2013
-
Abstract
- In the current study, a novel niosome based formulation of diallyl disulfide (DADS) was evaluated for its potential to treat disseminated candidiasis in mouse model. Among various non-ionic surfactants tested, niosome formulation prepared using Span 80 was found to be most efficient in the entrapment of DADS. The DADS loaded niosomes had size dimensions in the range of 140 ± 30 nm with zeta potential of -30.67 ± 4.5. Liver/kidney function tests as well as histopathologic studies suggested that noisome-based DADS formulations are safe at the dose investigated. When administered to Candida albicans infected animals, the DADS bearing niosomal formulation cleared the fungal burden and increased their survival much efficiently than its free form.<br />From the Clinical Editor: In this study, a novel niosomal formulation of the antifungal DADS was utilized in a murine candidiasis model, resulting in more efficient fungal clearance compared to the free formulation.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
- Subjects :
- Allyl Compounds administration & dosage
Allyl Compounds pharmacokinetics
Animals
Antifungal Agents administration & dosage
Antifungal Agents pharmacokinetics
Disulfides administration & dosage
Disulfides pharmacokinetics
Drug Carriers toxicity
Female
Hexoses toxicity
Mice
Mice, Inbred BALB C
Surface-Active Agents toxicity
Allyl Compounds therapeutic use
Antifungal Agents therapeutic use
Candida albicans drug effects
Candidiasis drug therapy
Disulfides therapeutic use
Drug Carriers chemistry
Hexoses chemistry
Surface-Active Agents chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22858760
- Full Text :
- https://doi.org/10.1016/j.nano.2012.07.004