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The food reaching test: a sensitive test of behavioral improvements by deep brain stimulation in MPTP-treated monkey.
- Source :
-
Neuroscience research [Neurosci Res] 2012 Oct; Vol. 74 (2), pp. 122-8. Date of Electronic Publication: 2012 Jul 28. - Publication Year :
- 2012
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Abstract
- We modified an objective behavioral test, namely the food reaching test (FRT), for quantitative assessment of motor performance improved by deep brain stimulation (DBS) of the subthalamic nucleus (STN) in the Parkinsonian monkeys. The symptomatic features and their severity in 3 monkeys treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were evaluated with a subjective monkey Parkinson's disease rating scale (PDRS). We then performed STN-DBS with the minimum current intensity that stopped the tremor. The time required for the monkeys to pick up all 5 pieces of potato (FRT time) was measured as a major index to evaluate bradykinesia. The success rate was adopted as another index for assessing overall motor impairments. Although both FRT time and PDRS score were similarly improved by STN-DBS, change of FRT time appeared more sensitive than that of PDRS scores. FRT is an easily trained behavioral test with high objectivity and sensitivity that can be applied for assessing motor performance in MPTP-treated monkeys during experiments in a restrained condition such as functional imaging of the brain.<br /> (Copyright © 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.)
- Subjects :
- Animals
Carbon Radioisotopes
Cocaine analogs & derivatives
Corpus Striatum diagnostic imaging
Corpus Striatum drug effects
Corpus Striatum pathology
Corpus Striatum physiopathology
Dihydroxyphenylalanine
Dopamine metabolism
Hypokinesia chemically induced
Hypokinesia diagnostic imaging
Hypokinesia physiopathology
Hypokinesia therapy
MPTP Poisoning diagnostic imaging
MPTP Poisoning physiopathology
Macaca fascicularis
Magnetic Resonance Imaging
Male
Radionuclide Imaging
Sensitivity and Specificity
Severity of Illness Index
Single-Blind Method
Time Factors
Treatment Outcome
Tremor chemically induced
Tremor diagnostic imaging
Tremor physiopathology
Tremor therapy
Deep Brain Stimulation
Feeding Behavior physiology
MPTP Poisoning therapy
Psychomotor Performance physiology
Subthalamic Nucleus physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8111
- Volume :
- 74
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neuroscience research
- Publication Type :
- Academic Journal
- Accession number :
- 22850123
- Full Text :
- https://doi.org/10.1016/j.neures.2012.07.006