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Usefulness of antibody index assessment in cerebrospinal fluid from patients negative for total-IgG oligoclonal bands.
- Source :
-
Fluids and barriers of the CNS [Fluids Barriers CNS] 2012 Jul 31; Vol. 9 (1), pp. 14. Date of Electronic Publication: 2012 Jul 31. - Publication Year :
- 2012
-
Abstract
- Background: Testing for cerebrospinal fluid (CSF)-restricted oligoclonal bands (OCB) by isoelectric focusing is used to detect intrathecally produced total IgG. By contrast, antibody indices (AI) are assessed to test for intrathecally produced antigen-specific IgG. A number of previous cases reports have suggested that AI testing might be more sensitive than OCB testing in detecting intrathecal IgG synthesis.<br />Findings: Here we report on 21 patients with positive AI for either herpes simplex virus, varicella zoster virus, cytomegalovirus, measles virus, rubella virus, or Borrelia burgdorferi in the absence of total-IgG OCB and, accordingly, in the presence of a normal total-IgG CSF/serum ratio.<br />Conclusion: Our findings indicate that AI testing should not generally be omitted in OCB-negative patients and provide a rationale for systematic and prospective studies on the comparative sensitivity and specificity of AI and total-IgG OCB testing in infectious and other diseases of the CNS.
Details
- Language :
- English
- ISSN :
- 2045-8118
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Fluids and barriers of the CNS
- Publication Type :
- Academic Journal
- Accession number :
- 22849518
- Full Text :
- https://doi.org/10.1186/2045-8118-9-14