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Gd-EOB-DTPA-enhanced MR imaging: prediction of hepatic fibrosis stages using liver contrast enhancement index and liver-to-spleen volumetric ratio.

Authors :
Goshima S
Kanematsu M
Watanabe H
Kondo H
Kawada H
Moriyama N
Bae KT
Source :
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2012 Nov; Vol. 36 (5), pp. 1148-53. Date of Electronic Publication: 2012 Jul 30.
Publication Year :
2012

Abstract

Purpose: To develop and evaluate a quantitative parameter for staging hepatic fibrosis by contrast enhancement signal intensity and morphological measurements from gadoxetic acid (Gd-EOB-DTPA)-enhanced MR imaging.<br />Materials and Methods: MR images were obtained in 93 patients; 75 patients had histopathologically proven hepatic fibrosis and 18 patients who had healthy livers were evaluated. The liver-to-muscle signal intensity ratio (SI(post) = SIliver/SImuscle), contrast enhancement index (CEI = SIpost/SIpre), and liver-to-spleen volumetric ratio (VR = Vliver/Vspleen) were evaluated for staging hepatic fibrosis.<br />Results: VR was most strongly correlated with fibrosis stage (7.21; r = -0.83; P < 0.001). Sensitivity, specificity, and area under the ROC curve demonstrated by linear regression formula generated by VR and CEI in predicting fibrous scores were 100%, 73%, and 0.91, respectively, for the detection of hepatic fibrosis F1 or greater (≥ F1),100%, 87%, and 0.96 for ≥ F2, 74%, 98%, and 0.93 for ≥ F3 and 91%, 100%, and 0.97 for F4.<br />Conclusion: The liver-to-spleen volumetric ratio and contrast enhancement index were reliable biomarkers for the staging of hepatic fibrosis on Gd-EOB-DTPA-enhanced MR imaging.<br /> (Copyright © 2012 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1522-2586
Volume :
36
Issue :
5
Database :
MEDLINE
Journal :
Journal of magnetic resonance imaging : JMRI
Publication Type :
Academic Journal
Accession number :
22848019
Full Text :
https://doi.org/10.1002/jmri.23758