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Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna.
- Source :
-
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2013 Feb; Vol. 31 (2), pp. 235-42. Date of Electronic Publication: 2012 Jul 30. - Publication Year :
- 2013
-
Abstract
- Anti-inflammatory drugs are widely used to manage pain associated with stress fractures (SFxs), but little is known about their effects on healing of those injuries. We hypothesized that selective and non-selective anti-inflammatory treatments would retard the healing of SFx in the rat ulna. SFxs were created by cyclic loading of the ulna in Wistar rats. Ulnae were harvested 2, 4 or 6 weeks following loading. Rats were treated with non-selective NSAID, ibuprofen (30 mg/kg/day); selective COX-2 inhibition, [5,5-dimethyl-3-3 (3 fluorophenyl)-4-(4 methylsulfonal) phenyl-2 (5H)-furanone] (DFU) (2.0 mg/kg/day); or the novel c5a anatagonist PMX53 (10 mg/kg/day, 4 and 6 weeks only); with appropriate vehicle as control. Quantitative histomorphometric measurements of SFx healing were undertaken. Treatment with the selective COX-2 inhibitor, DFU, reduced the area of resorption along the fracture line at 2 weeks, without affecting bone formation at later stages. Treatment with the non-selective, NSAID, ibuprofen decreased both bone resorption and bone formation so that there was significantly reduced length and area of remodeling and lamellar bone formation within the remodeling unit at 6 weeks after fracture. The C5a receptor antagonist PMX53 had no effect on SFx healing at 4 or 6 weeks after loading, suggesting that PMX53 would not delay SFx healing. Both selective COX-2 inhibitors and non-selective NSAIDs have the potential to compromise SFx healing, and should be used with caution when SFx is diagnosed or suspected.<br /> (Copyright © 2012 Orthopaedic Research Society.)
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal pharmacology
Bone Remodeling drug effects
Bone Resorption drug therapy
Complement C5a antagonists & inhibitors
Cyclooxygenase 2 Inhibitors adverse effects
Fracture Healing drug effects
Fractures, Bone drug therapy
Fractures, Stress pathology
Furans adverse effects
Ibuprofen adverse effects
Osteogenesis drug effects
Rats
Rats, Wistar
Ulna pathology
Cyclooxygenase 2 Inhibitors pharmacology
Fractures, Stress drug therapy
Furans pharmacology
Ibuprofen pharmacology
Peptides, Cyclic pharmacology
Ulna injuries
Subjects
Details
- Language :
- English
- ISSN :
- 1554-527X
- Volume :
- 31
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of orthopaedic research : official publication of the Orthopaedic Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 22847634
- Full Text :
- https://doi.org/10.1002/jor.22203