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Time-resolved influences of functional DAT1 and COMT variants on visual perception and post-processing.
- Source :
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PloS one [PLoS One] 2012; Vol. 7 (7), pp. e41552. Date of Electronic Publication: 2012 Jul 23. - Publication Year :
- 2012
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Abstract
- Background: Dopamine plays an important role in orienting and the regulation of selective attention to relevant stimulus characteristics. Thus, we examined the influences of functional variants related to dopamine inactivation in the dopamine transporter (DAT1) and catechol-O-methyltransferase genes (COMT) on the time-course of visual processing in a contingent negative variation (CNV) task.<br />Methods: 64-channel EEG recordings were obtained from 195 healthy adolescents of a community-based sample during a continuous performance task (A-X version). Early and late CNV as well as preceding visual evoked potential components were assessed.<br />Results: Significant additive main effects of DAT1 and COMT on the occipito-temporal early CNV were observed. In addition, there was a trend towards an interaction between the two polymorphisms. Source analysis showed early CNV generators in the ventral visual stream and in frontal regions. There was a strong negative correlation between occipito-temporal visual post-processing and the frontal early CNV component. The early CNV time interval 500-1000 ms after the visual cue was specifically affected while the preceding visual perception stages were not influenced.<br />Conclusions: Late visual potentials allow the genomic imaging of dopamine inactivation effects on visual post-processing. The same specific time-interval has been found to be affected by DAT1 and COMT during motor post-processing but not motor preparation. We propose the hypothesis that similar dopaminergic mechanisms modulate working memory encoding in both the visual and motor and perhaps other systems.
- Subjects :
- Adolescent
Behavior physiology
Contingent Negative Variation genetics
Female
Humans
Male
Memory physiology
Motor Activity genetics
Motor Activity physiology
Photic Stimulation
Time Factors
Catechol O-Methyltransferase genetics
Catechol O-Methyltransferase metabolism
Dopamine Plasma Membrane Transport Proteins genetics
Dopamine Plasma Membrane Transport Proteins metabolism
Polymorphism, Genetic
Visual Perception genetics
Visual Perception physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 7
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 22844499
- Full Text :
- https://doi.org/10.1371/journal.pone.0041552