Back to Search
Start Over
Ultrastructurally confirmed myofibrosarcoma: a series of 10 new cases, with a discussion on diagnostic criteria.
- Source :
-
International journal of surgical pathology [Int J Surg Pathol] 2013 Feb; Vol. 21 (1), pp. 29-36. Date of Electronic Publication: 2012 Jul 27. - Publication Year :
- 2013
-
Abstract
- Some view ultrastructure as key to myofibrosarcoma diagnosis, whereas others argue that electron microscopy is too little used in contemporary practice to be considered an important diagnostic tool. These views are discussed in the context of 10 ultrastructurally confirmed cases of myofibrosarcoma, some occurring at rare sites such as skin and penis. Patient age ranged from 21 to 83 years, with a 6:4 male to female ratio. Size ranged from 2 to 7.5 cm and all had infiltrative margins. Histologically, all consisted of variably cellular fascicles of spindle cells with mild to moderately pleomorphic nuclei, small punctate nucleoli, and eosinophilic cytoplasm. All cases showed α-smooth muscle actin positivity and 2 showed very focal weak positivity for desmin. Ultrastructurally, the tumor cells contained rough endoplasmic reticulum, mainly peripheral smooth-muscle myofilaments, and fibronectin fibrils or fibronexus junctions at the cell surface. The most confident diagnosis of myofibrosarcoma is provided by ultrastructural examination. However, given the right histological appearance, use of a panel of antibodies that includes α-smooth muscle actin, desmin, and h-caldesmon, serves as an acceptable practical way of diagnosing myofibrosarcoma.
- Subjects :
- Actins metabolism
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor metabolism
Desmoplastic Small Round Cell Tumor diagnosis
Diagnosis, Differential
Endoplasmic Reticulum, Rough ultrastructure
Fatal Outcome
Female
Fibronectins ultrastructure
Fibrosarcoma metabolism
Humans
Immunohistochemistry methods
Male
Melanoma diagnosis
Microscopy, Electron, Transmission
Middle Aged
Muscle, Smooth ultrastructure
Myofibrils ultrastructure
Myosarcoma metabolism
Neoplasm Recurrence, Local
Penis pathology
Sarcoma diagnosis
Skin Neoplasms metabolism
Xanthomatosis diagnosis
Young Adult
Fibrosarcoma secondary
Myosarcoma secondary
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1940-2465
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of surgical pathology
- Publication Type :
- Academic Journal
- Accession number :
- 22843641
- Full Text :
- https://doi.org/10.1177/1066896912454568