Back to Search
Start Over
Isolation and characterization of propoxyphenyl linked sildenafil and thiosildenafil analogues in health supplements.
- Source :
-
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2012 Nov; Vol. 70, pp. 265-72. Date of Electronic Publication: 2012 Jul 16. - Publication Year :
- 2012
-
Abstract
- Two new phosphodiesterase-5 inhibitors (PDE-5) which consist of one sildenafil analogue and one thiosildenafil analogue have been found in heath supplements. The structural properties of these analogues have been elucidated by NMR, high resolution MS, MS(2), UV and IR spectroscopy. The sildenafil analogue is very similar to aildenafil and the thiosildenafil analogue is similar to thioaildenafil, except the ethoxy group bonded to phenyl ring is replaced by a propoxy group. Hence, the sildenafil analogue is named as propoxyphenyl aildenafil or propoxyphenyl methisosildenafil and the thiosildenafil analogue as propoxyphenyl thioaildenafil or propoxyphenyl thiomethisosildenafil.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Chromatography, High Pressure Liquid
Magnetic Resonance Spectroscopy
Molecular Structure
Phosphodiesterase 5 Inhibitors chemistry
Piperazines chemistry
Purines chemistry
Purines isolation & purification
Pyrimidines chemistry
Sildenafil Citrate
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Sulfones chemistry
Tandem Mass Spectrometry
Dietary Supplements analysis
Drug Contamination
Phosphodiesterase 5 Inhibitors isolation & purification
Piperazines isolation & purification
Pyrimidines isolation & purification
Sulfones isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-264X
- Volume :
- 70
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical and biomedical analysis
- Publication Type :
- Academic Journal
- Accession number :
- 22840979
- Full Text :
- https://doi.org/10.1016/j.jpba.2012.07.008