Detection of new methicillin-resistant Staphylococcus aureus strains that carry a novel genetic homologue and important virulence determinants.

Authors :: Sabat AJ
Koksal M
Akkerboom V
Monecke S
Kriegeskorte A
Hendrix R
Ehricht R
Köck R
Becker K
Friedrich AW
Source :: Journal of clinical microbiology [J Clin Microbiol] 2012 Oct; Vol. 50 (10), pp. 3374-7. Date of Electronic Publication: 2012 Jul 25.
Publication Year :: 2012
Abstract: In this study, 18 methicillin-resistant Staphylococcus aureus (MRSA) isolates harboring staphylococcal cassette chromosome mec (SCCmec) type XI, recovered in the Dutch-German Euregio, were characterized by DNA microarrays. In contrast to previous data, we found two MRSA strains of different clonal lineages possessing SCCmec XI that carried important virulence determinants. The worrisome emergence of such toxigenic MRSA strains raises concerns that MRSA strains with enhanced virulence potential and impaired detectability by standard molecular assays may spread in Europe.

Subjects :: Anti-Bacterial Agents pharmacology
Cluster Analysis
Germany epidemiology
Humans
Methicillin-Resistant Staphylococcus aureus classification
Microarray Analysis
Microbial Sensitivity Tests
Molecular Typing
Netherlands epidemiology
Oligonucleotide Array Sequence Analysis
Methicillin-Resistant Staphylococcus aureus genetics
Methicillin-Resistant Staphylococcus aureus isolation & purification
Staphylococcal Infections epidemiology
Staphylococcal Infections microbiology
Virulence Factors genetics

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