An amphiphilic dendrimer for effective delivery of small interfering RNA and gene silencing in vitro and in vivo.

Authors :: Yu T
Liu X
Bolcato-Bellemin AL
Wang Y
Liu C
Erbacher P
Qu F
Rocchi P
Behr JP
Peng L
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2012 Aug 20; Vol. 51 (34), pp. 8478-84. Date of Electronic Publication: 2012 Jul 24.
Publication Year :: 2012
Abstract: An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and dendrimer vectors to deliver a heat shock protein 27 siRNA and produce potent gene silencing and anticancer activity in vitro and in vivo in a prostate cancer model. This dendrimer can be used alternatively for treating various diseases.<br /> (Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Dendrimers chemical synthesis
Genetic Therapy methods
Genetic Vectors genetics
HSP27 Heat-Shock Proteins genetics
Humans
Male
Prostatic Neoplasms genetics
Prostatic Neoplasms therapy
RNA, Small Interfering genetics
Dendrimers administration & dosage
Dendrimers chemistry
Gene Silencing
Genetic Vectors administration & dosage
Genetic Vectors chemistry
RNA, Small Interfering administration & dosage
RNA, Small Interfering chemistry

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