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A Bayesian analysis of the chromosome architecture of human disorders by integrating reductionist data.
- Source :
-
Scientific reports [Sci Rep] 2012; Vol. 2, pp. 513. Date of Electronic Publication: 2012 Jul 20. - Publication Year :
- 2012
-
Abstract
- In this paper, we present a Bayesian approach to estimate a chromosome and a disorder network from the Online Mendelian Inheritance in Man (OMIM) database. In contrast to other approaches, we obtain statistic rather than deterministic networks enabling a parametric control in the uncertainty of the underlying disorder-disease gene associations contained in the OMIM, on which the networks are based. From a structural investigation of the chromosome network, we identify three chromosome subgroups that reflect architectural differences in chromosome-disorder associations that are predictively exploitable for a functional analysis of diseases.
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 2
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 22822426
- Full Text :
- https://doi.org/10.1038/srep00513